Cancer is the second leading cause of death in the world, and responsible for 9.9 million deaths in 2020. The current cancer treatments have shown ineffective results, and caused side effects on normal cells. Shield lichen, whose presence is often ignored, contains various secondary metabolites, such as palmitic acid, flavonoid, alkaloid, steroid, triterpenoid, tannin, and saponin. These contents are presumed to be able to inhibit angiogenesis, thus inhibiting the growth of cancer cells. Palmitic acid is an angiogenesis inhibitor that is often used. Therefore, the angiogenesis potential of shield lichen is necessary to be compared with palmitic acid, thus it could be an innovative solution for a safe and effective natural anticancer drug. The extraction of secondary metabolites from shield lichen was done using 96% ethanol. Identification of secondary metabolite contents in the shield lichen extract was carried out through phytochemical screening using reagents, and are confirmed by FTIR (Fourier-transform Infrared) Spectroscopy. The anticancer potential test was performed by examining the angiogenesis inhibition potential of the extract and palmitic acid, on the chick chorioallantoic membrane, using in ovo CAM assay method. Antiangiogenesis potential was done using 3 variations of extract concentration, 5%, 10%, and 15%, compared with palmitic acid. The absence of blood vessel growth indicates a great potential of angiogenesis inhibition. The fewer the blood vessels that grow, the greater the angiogenesis inhibition potential. The results show that the secondary metabolites from shield lichen can be extracted through maceration using 96% ethanol. The phytochemical screening, which was confirmed by FTIR, proves the presence of flavonoid, alkaloid, triterpenoid, steroid, tannin, saponin, and palmitic acid, in shield lichen extract. Angiogenesis inhibition potential of shield lichen extract towards chick chorioallantoic membrane surpasses palmitic acid at 5% concentration, although they are equivalent at 10% and 15% concentration. From these study results, we can conclude that shield lichen extract has potential in inhibiting angiogenesis, surpassing palmitic acid. Therefore, it serves as an innovative solution for a safe and effective natural anticancer drug.