In the experiment, I fabricated Ni, In, Sn, Ag, and Au nanoparticles with the thermal evaporation method and successfully produced small water clusters by utilizing their features: electron blockade (EBK) and surface plasma resonance (SPR). According to the result, five Raman vibration modes were detected from deionized water, while two at 3506 and 3624 cm-1 signify small water clusters. Interestingly, the enhancement of Ni, Sn, and In nanoparticles is much better than that of Ag and Au nanoparticles in both methods. For applications, small water clusters may promote the growth rate of apple snails and waterweeds or even improve the viability of cells and the efficacy of a drug for cancer.